Andrea Corr has been a very close friend to Bono, Gavin & Guggi (the "unholy" trinity) for years. She is always seen with one of them with their arms around her. They are a close knit group that likes to show affection.
As far as Penelope goes, this one gets me so angry. Penelope has gone on record several times just how angry she was when they conveniently cut out Ali and the children from that famous shot. Bono is very fond of Penelope and she is very active in his (RED) campaign.
He is extremely close to Christy Turlington and Helena Christensen who are also very active in ONE and Chernobyl Children's Fund. These ladies help Ali in that charity and are very close to her as well.
You can think what you want....and yeah....anything is possible. But I venture to guess Bono never cheated on his Mrs. Ladies like Ali don't come around too often and Bono is smart enough to know that and know that Ali would never accept that kind of behavior . Just my humble opinion