I probably wouldn't have changed anything up until after HTDAAB. Granted, ATYCLB wasn't my favorite album of theirs, but I understand they probably HAD to "return to their roots", at least musically. I got a lot of enjoyment out of those tours, too.
If anything, maybe HTDAAB would have been more of what SOI was. I could almost see a double album in there somewhere, using the theme of looking back at their history and early days.
But in my timeline, Bono and Edge had nothing to do with Spider-Man, and NLOTH didn't happen, at least not as it currently is.