Personally, I think that with 40 or so hit singles, U2 should and can mix it up a little : not in terms of playing "Lady With Spinning Head", but to have rotating hits such as I Will Follow, Out Of Control, Desire, When Love Comes To Town, All I Want Is You, Fly, Even Better, Wild Horses, Numb, Discotheque, Please, Sometimes, ABOY, Saints, Windows In The Skies should be in there.
Also, mix up the running order : put "One" in the middle, for example. I've long been tinkering with sets, and even if they don't add new songs, maybe they should move some around - open with "Magnificent", put "Breathe" as the post-acoustic song, throw "Unknown Caller" to a different spot, follow "Crazy" with "Vertigo" in the first third of the show..
Once you get to "Blinding Lights", the sets on this tour are 95% identical, the only question there is at that point is "Bad - or not?"